Patriots vs Bills

Buffalo has shown a weakness against teams who commit to heavy personnel in the run game (see the Titans and Colts games for examples) and that suits the Patriots fine. They love to run the ball and Harris has seen most of those snaps of late. Averaging 58.5 yards per game, he only has to maintain that level to go over his number here. 

• Damien Harris Over 52.5 Rushing Yards